| 產(chǎn)品編號 | bs-19226R-APC |
| 英文名稱1 | Rabbit Anti-NFRKB/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的DNA結(jié)合蛋白κB抗體 |
| 別 名 | A530090G11Rik; DKFZp547B2013; DNA binding protein R kappa B; INO80 complex subunit G; INO80G; Nuclear factor related to kappa B binding protein; Nuclear factor related to kappaB binding protein. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 轉(zhuǎn)錄調(diào)節(jié)因子 結(jié)合蛋白 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 139kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NFRKB |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: DNA-binding protein R kappa-B, is a nuclear protein that binds to the DNA consensus sequence 5'-GGGGAATCTCC-3' of NF kappa B. Binding of NFR kappa B is thought to regulate IL-2R alpha (interleukin-2 receptor alpha-chain) gene expression, a critical step in T-cell activation. NFR kappa B exists as 3 isoforms due to alternative splicing and is expressed primarily in the brain, liver, spleen, testis and thymus NFR kappa B gene expression is amplified in acute myeloid leukemia, suggesting a possible role in carcinogenesis. Function: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. Subcellular Location: Nuclear Tissue Specificity: Expressed in thymus, brain, testes, spleen and liver. Database links: Entrez Gene: 419727 Chicken Entrez Gene: 419730 Chicken Entrez Gene: 4798 Human Entrez Gene: 235134 Mouse Omim: 164013 Human SwissProt: Q6P4R8 Human SwissProt: Q6PIJ4 Mouse Unigene: 530539 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
