| 產(chǎn)品編號 | bs-8873R-PE |
| 英文名稱1 | Rabbit Anti-CD36/PE Conjugated antibody |
| 中文名稱 | PE標(biāo)記的CD36抗體 |
| 別 名 | Platelet glycoprotein IV; GPIV; lycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; Platelet collagen receptor; Fatty acid translocase; FAT; Thrombospondin receptor; CD36_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞表面分子 細(xì)胞類型標(biāo)志物 血管內(nèi)皮細(xì)胞 內(nèi)皮細(xì)胞 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Chicken, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 53kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD36/PAS-4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: CD36 is a membrane glycoprotein on platelets, monocytes and umbilical vein endothelial cells. CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. CD36 plays a key role in both phagocytosis and lipid recycling, for constant production of mature spermatozoa. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Thrombospondins are widely distributed proteins that influence a variety of adhesive processes and CD36 may have important functions as a cell adhesion molecule. Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects. Subunit: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Subcellular Location: Membrane; Multi-pass membrane protein. Post-translational modifications: N-glycosylated and O-glycosylated with a ratio of 2:1. DISEASE: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938]. Similarity: Belongs to the CD36 family. Database links: Entrez Gene: 948 Human Entrez Gene: 12491 Mouse Omim: 173510 Human SwissProt: P16671 Human SwissProt: Q08857 Mouse Unigene: 120949 Human Unigene: 18628 Mouse Unigene: 406799 Mouse Unigene: 102418 Rat Unigene: 205840 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD36屬一種多功能細(xì)胞膜受體，CD36參與長鏈脂肪酸的吸附和調(diào)節(jié)細(xì)胞凋亡殘物的清理和巨噬細(xì)胞的吞噬作用， 屬于一種抗蛋白酶血小板膜表面糖蛋白。 CD36 廣泛在單核細(xì)胞、巨噬細(xì)胞、內(nèi)皮層細(xì)胞、血小板、紅細(xì)胞前板、脂肪細(xì)胞、肌肉細(xì)胞以及乳腺內(nèi)皮層細(xì)胞中有不同的表達(dá)。CD36抗原是血小板反應(yīng)素的配體，兩者結(jié)合后產(chǎn)生抑制腫瘤血管生成的效應(yīng)。 |
