| 產(chǎn)品編號 | bs-13372R-AP |
| 英文名稱1 | Rabbit Anti-GLEPP1/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的腎小球上皮蛋白1抗體 |
| 別 名 | FMI; GLEPP 1; Glomerular epithelial protein 1; hPTP-J; Pancreatic carcinoma phosphatase 2; PCP-2; PCP2; Phosphotyrosine phosphatase U2; Protein tyrosine phosphatase PTP U2; Protein tyrosine phosphatase PTPU2; Protein tyrosine phosphatase receptor type O; Protein tyrosine phosphatase U2; Protein-tyrosine phosphatase J; Protein-tyrosine phosphatase pi; Protein-tyrosine phosphatase receptor omicron; PTP pi; PTP U2; PTP-J; PTP-RO; PTP-U2; PTPase U2; PTPRO; PTPRO_HUMAN; PTPROt; PTPU 2; PTPU2; R-PTP-O; R-PTP-psi; Receptor type protein tyrosine phosphatase O; Receptor type tyrosine protein phosphatase O; Receptor-type protein-tyrosine phosphatase psi; Receptor-type tyrosine-protein phosphatase O; Receptor-type tyrosine-protein phosphatase U. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Horse, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 135kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GLEPP1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Protein phosphatases play critical roles in the regulation of signal transduction pathways. The family can be separated into three general categories, which are distinguished on the basis of substrate specificity. The first and largest category, termed protein tyrosine phosphatases or PTPs, includes transmembrane proteins, membrane associated proteins and proteins that localize to nuclei. The second category of protein phosphatases dephosphorylate proteins on phosphoserine and phosphothreonine residues, whereas the third category of protein phosphatases exhibit dual specificities and can dephosphorylate proteins on phosphotyrosine and phosphoserine/phosphothreonine residues. Glomerular epithelial protein 1 (GLEPP1), also designated protein tyrosine phosphatase U2 (PTPase U2) or receptor-type tyrosine-protein phosphatase O (PTPRO), belongs to the protein-tyrosine phosphatase family. GLEPP1 is a Type I membrane protein containing 8 fibronectin type-III domains and 1 tyrosine-protein phosphatase domain. GLEPP1 is expressed primarily in the glomeruli of the kidney, but is also detected in placenta, lung and brain. Function: Possesses tyrosine phosphatase activity. Subcellular Location: Membrane. Tissue Specificity: Glomerulus of kidney. Also detected in brain, lung and placenta. DISEASE: Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6) [MIM:614196]. NPHS6 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. Contains 8 fibronectin type-III domains. Contains 1 tyrosine-protein phosphatase domain. Database links: Entrez Gene: 5800 Human Omim: 600579 Human SwissProt: Q16827 Human Unigene: 160871 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
