| 產(chǎn)品編號 | bs-1253R-BF488 |
| 英文名稱1 | Rabbit Anti-AQP3/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的水通道蛋白-3抗體 |
| 別 名 | AQP 3; AQP3; Aquaporin 3 (GIL blood group); Aquaporin 3 (Gill blood group); Aquaporin3; Aquaporin-3; GIL; Gill blood group; AQP3_MOUSE. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 信號轉(zhuǎn)導(dǎo) 通道蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse AQP3 C-terminus |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011] Function: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Renal medulla and colon. Predominantly in the inner medulla. Expressed in basal layer of epidermal keratinocytes. Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family. Database links: Entrez Gene: 360 Human Entrez Gene: 11828 Mouse Omim: 600170 Human SwissProt: Q92482 Human SwissProt: Q8R2N1 Mouse Unigene: 234642 Human Unigene: 34043 Mouse Unigene: 11109 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 通道蛋白（Channel Protein） AQP 3主要分布于腎臟集合管上皮細(xì)胞基側(cè)質(zhì)膜,除了對水有通透性外、還可轉(zhuǎn)運尿素和甘油等小分子物質(zhì),而尿素在尿液濃縮機(jī)制中有著重要的作用. 有學(xué)者認(rèn)為：AQP-3的陽性率與某些腫瘤分化程度有關(guān)（胃癌、結(jié)腸癌、乳腺癌、前列腺癌、子宮癌、卵巢癌、甲狀腺癌等） |
