| 產(chǎn)品編號(hào) | bs-4769R-BF488 |
| 英文名稱1 | Rabbit Anti-Metabotropic Glutamate Receptor 2/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的促代謝型谷氨酸受體2抗體 |
| 別 名 | Glutamate Receptor Metabotropic 2; Gprc1b; AMPA selective glutamate receptor 2; GLUR 2; GLUR2; GLURB; Glutamate receptor metabotropic 2; Metabotropic Glutamate Receptor 2; GPRC1B; GRM 2; Grm2; mGlu 2; MGlu2; MGLUR 2; Mglur2; GRM2_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 96kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GRM2/GLUR2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Subunit: Interacts with GRASP (By similarity). Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in different regions of the adult brain as well as in fetal brain. Similarity: Belongs to the G-protein coupled receptor 3 family. Database links:
Entrez Gene: 2912 Human
Entrez Gene: 108068 Mouse
Omim: 604099 Human
SwissProt: Q14416 Human
SwissProt: Q14BI2 Mouse
Unigene: 121510 Human
Unigene: 410822 Mouse
Unigene: 424639 Mouse
Unigene: 9681 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 谷氨酸受體-代謝能2；主要參與細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)及突觸傳遞，在G蛋白偶聯(lián)受體蛋白信號(hào)轉(zhuǎn)導(dǎo)途徑中有一定的作用，并且有負(fù)調(diào)控腺苷酸環(huán)化酶的作用，為膜性蛋白，在胞膜、胞漿中表達(dá)。 |
