| 產(chǎn)品編號(hào) | bs-8163R-AP |
| 英文名稱 | Rabbit Anti-TCAB1/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的端粒酶卡哈爾體蛋白抗體 |
| 別 名 | FLJ10385; TCAB1; telomerase Cajal Body protein 1; WD repeat containing protein 79; WRAP53; WDR79/TCAB1; WAP53_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 60kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human WDR79/TCAB1（304-347aa） |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: WDR79 contains six WD (tryptophan-aspartate) repeat domains found in a number of proteins that function as adaptor molecules in signal transduction and cytoskeletal organization. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. The function of the WDR79 protein has not been characterized, however significant and consistent single nucleotide polymorphisms in the WDR79 gene have been found to be associated with ER negative breast cancer. Function: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage. Subunit: Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Subcellular Location: Nucleus, Cajal body. Cytoplasm. Tissue Specificity: Expressed in all tissues and cell lines examined. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Defects in WRAP53 are the cause of dyskeratosis congenital autosomal recessive type 3 (DKCB3) [MIM:613988]. A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. Similarity: Contains 6 WD repeats Database links: UniProtKB/Swiss-Prot: Q9BUR4.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TCAB1是端粒酶的一個(gè)真正組成部分。但它對(duì)酶的活性來(lái)說(shuō)并不是必需的，它只是給稱為卡哈爾體（Cajalbodies）的細(xì)胞核中的處理和保持區(qū)域補(bǔ)充端粒酶復(fù)合物?？ü栿w將對(duì)各種使用RNA小分子來(lái)引領(lǐng)其活性的蛋白進(jìn)行修飾，譬如，端粒酶使用RNA分子作為嵌在染色體末端的DNA鏈的模板。在適當(dāng)?shù)臅r(shí)候，TCAB1將端粒酶復(fù)合物運(yùn)送到新復(fù)制染色體的等待端。 研究人員認(rèn)為，TCAB1蛋白可能是一種負(fù)責(zé)將各種分子運(yùn)往其目的地的普通生物運(yùn)輸器。 |
