| 產(chǎn)品編號 | bs-6792R-Cy5.5 |
| 英文名稱 | Rabbit Anti-Apaf1 Interacting Protein/Cy5.5 Conjugated antibody |
| 中文名稱 | Cy5.5標(biāo)記的凋亡蛋白活性因子1相互作用蛋白抗體 |
| 別 名 | MTNB_HUMAN; Apaf1 Interacting Protein; APIP2; CG129; CGI 29; MMRP19; MTRu 1 P dehydratase; Probable methylthioribulose 1 phosphate dehydratase. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細胞生物 信號轉(zhuǎn)導(dǎo) 細胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human APIP (178-225aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c-dependent and APAF1-mediated cell death. Subunit: Interacts with APAF1. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitously expressed with high expression in skeletal muscle, heart and kidney. Similarity: Belongs to the aldolase class II family. MtnB subfamily. Database links: Entrez Gene: 32334 Fruit fly (Drosophila melanogaster) Entrez Gene: 100732536 Guinea pig Entrez Gene: 51074 Human Entrez Gene: 56369 Mouse Entrez Gene: 447941 Zebrafish Omim: 612491 Human SwissProt: Q9VY93 Fruit fly (Drosophila melanogaster) SwissProt: Q96GX9 Human SwissProt: Q8BP46 Mouse SwissProt: Q9WVQ5 Mouse SwissProt: Q66I75 Zebrafish Unigene: 5343 Fruit fly (Drosophila melanogaster) Unigene: 447794 Human Unigene: 24772 Mouse Unigene: 15452 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
