| 產(chǎn)品編號 | bs-3311R-Gold |
| 英文名稱1 | Rabbit Anti-Phospho-Numb (Ser276)/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的磷酸化膜相關(guān)蛋白Numb抗體 |
| 別 名 | Numb (phospho S276); Numb (phospho Ser276); p-Numb (Ser276); c14_5527; C14orf41; FLJ31314; h Numb; h-Numb; Numb; Numb homolog (Drosophila); Numb homolog; Numb protein homolog; NUMB_HUMAN; Protein numb homolog; Protein S171; S171. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 細胞生物 免疫學(xué) 神經(jīng)生物學(xué) 細胞膜受體 細胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 70kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Numb around the phosphorylation site of Ser276 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Subunit: Interacts with CDH1 and TFAP2B (By similarity). Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. Subcellular Location: Membrane; Peripheral membrane protein. Post-translational modifications: Phosphorylated on Ser-276 and Ser-295 by CaMK1. Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation. Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. Similarity: Contains 1 PID domain. Database links: Entrez Gene: 8650 Human Entrez Gene: 18222 Mouse Omim: 603728 Human SwissProt: P49757 Human SwissProt: Q9QZS3 Mouse Unigene: 654609 Human Unigene: 714879 Human Unigene: 4390 Mouse Unigene: 102078 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 膜相關(guān)蛋白Numb是細胞命運決定因子：在細胞有絲分裂期，Numb選擇性地分布于細胞的一側(cè),在胞質(zhì)分裂后則被分配于一個子細胞，Numb通過抑制跨膜受體Notch而發(fā)揮作用, Numb信號途徑在前體細胞的神經(jīng)元調(diào)控方面起著重要作用. |
