| 產(chǎn)品編號 | bs-2794R-BF488 |
| 英文名稱1 | Rabbit Anti-RGS5/BF488 Conjugated antibody |
| 中文名稱 | BF488標記的G蛋白信號轉(zhuǎn)導調(diào)節(jié)因子5抗體 |
| 別 名 | MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129; Regulator of G Protein Signalling 5; RGS 5; RGS5_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領域 | 腫瘤 細胞生物 信號轉(zhuǎn)導 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Mouse, (predicted: Human, Rat, Dog, Pig, Rabbit, ) |
| 產(chǎn)品應用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse RGS5 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. RGS5 seems to be an important signalling regulator in the vascular system. Present data suggest that RGS5 may be involved in the regulation of capillary growth, angiogenesis, and in the pathophysiology of stroke. Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Similarity: Contains 1 RGS domain. Database links: Entrez Gene: 8490 Human Entrez Gene: 19737 Mouse Omim: 603276 Human SwissProt: O15539 Human SwissProt: O08850 Mouse Unigene: 24950 Human Unigene: 20954 Mouse Unigene: 1150 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. RGS5是調(diào)控G-蛋白活性的信號蛋白（RGS）家族的一員，是腫瘤血管形成的一個重要調(diào)控因子.主要與G蛋白α亞基結(jié)合，發(fā)揮GTP酶激活蛋白（GAPs）作用，負性調(diào)節(jié)G蛋白信號傳導途徑。Rgs5在體內(nèi)多個器官都有表達，主要表達于這些組織器官的血管周細胞。 近期發(fā)現(xiàn)，Rgs5與血管的生成、發(fā)展及成熟有密切關系，影響全身各系統(tǒng)功能。同時在一些腫瘤組織和細胞中也有高表達，且與腫瘤血管的異常有關。Rgs5基因的缺失可以使得腫瘤血管正常化，并促進免疫治療的效果，提示其可能成為抗腫瘤血管治療的新靶點。另外RGS5也可能是一種腫瘤相關抗原．對腫瘤診斷及治療有著積極的意義． |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
