| 產(chǎn)品編號(hào) | bs-2101R-AP |
| 英文名稱1 | Rabbit Anti-TEM1/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的內(nèi)涎蛋白/內(nèi)皮唾液酸蛋白抗體 |
| 別 名 | Tumor endothelial marker 1 precursor; TEM 1; TEM-1; tumor endothelial marker 1; CD248; Endosialin; Tumor endothelial marker 1; CD164L1; MGC119478; MGC119479. CD164 sialomucin-like 1; CD248_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞凋亡 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 80kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TEM 1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The transmembrane glycoprotein Tumor endothelial marker 1 (TEM1) is highly expressed in tumor endothelial cells however it is barely detectable on normal endothelial cells. It is believed to play a role in tumor angiogenesis. It is expressed in stromal fibroblasts, metastatic hepatic lesions and during angiogenesis of corpus luteum formation and wound healing. TEM1 is being investigated as a potential target for cancer treatment. Function: May play a role in tumor angiogenesis. Subcellular Location: Membrane; Single-pass type I membrane protein (Probable). Tissue Specificity: Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts. Post-translational modifications: O-glycosylated with sialylated oligosaccharides. May be N-glycosylated. Similarity: Contains 1 C-type lectin domain. Contains 1 EGF-like domain.Contains 1 Sushi (CCP/SCR) domain. Database links: Entrez Gene: 57124 Human Entrez Gene: 70445 Mouse Omim: 606064 Human SwissProt: Q9HCU0 Human SwissProt: Q91V98 Mouse Unigene: 195727 Human Unigene: 29597 Mouse Unigene: 38806 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 內(nèi)皮唾液酸蛋白（CD248）是近年發(fā)現(xiàn)的人類腫瘤標(biāo)記物之一,在人類多種惡性腫瘤組織中異常高表達(dá),內(nèi)皮唾液酸蛋白對(duì)腫瘤細(xì)胞生長(zhǎng)、血管生成、浸潤(rùn)及轉(zhuǎn)移有重要作用。 |
