| 產(chǎn)品編號 | IHC0565R |
| 英文名稱 | Rat JAK1 Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠蛋白質(zhì)酪氨酸激酶JAK-1即用型免疫組化試劑盒 |
| 別 名 | AA960307; BAP004; C130039L05Rik; JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; JAK1_HUMAN |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events. SWISS: P23458 Gene ID: 3716 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Rat kidney tissue slide using IHC0565R (Rat JAK1 Kit).
|
