| 產(chǎn)品編號(hào) | IHC0558M |
| 英文名稱 | Mouse CDK4 Ready-To-Use IHC Kit |
| 中文名稱 | 小鼠周期素依賴性激酶4即用型免疫組化試劑盒 |
| 別 名 | PSK-J3; Cdk 4; CDK4 protein; Cell division kinase 4; Cell division protein kinase 4; CMM 3; CMM3; Crk3; Cyclin dependent kinase 4; Melanoma cutaneous malignant 3; MGC14458; p34 cdk4; PSK J3; CDK4_HUMAN |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein. SWISS: P11802 Gene ID: 1019 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Mouse liver tissue slide using IHC0558M (Mouse CDK4 Kit).
Immunohistochemical analysis of paraffin embedded Mouse lung tissue slide using IHC0558M (Mouse CDK4 Kit).
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