| 產(chǎn)品編號(hào) | IHC0556H |
| 英文名稱 | Human CD22 Ready-To-Use IHC Kit |
| 中文名稱 | 人B淋巴細(xì)胞粘附分子CD22即用型免疫組化試劑盒 |
| 別 名 | CD22; SIGLEC-2; SIGLEC2; BL-CAM; Leu-14; FLJ22814; MGC130020 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CD22, also known as BL-CAM, is a type I transmembrane glycoprotein composed of two polypeptide chains, CD22alpha and CD22beta, with molecular weights of 130 and 140 kDa, respectively. These chains are produced by alternative splicing of the CD22 gene. CD22 is prominently expressed on mature B cells and B cell lymphomas, including hairy cell leukemia, diffuse large B-cell lymphoma, and nodular lymphocyte predominance Hodgkin's lymphoma, but is negative in classical Hodgkin's lymphoma. The extracellular portion of CD22 contains seven Ig-like domains that preferentially bind alpha2,6-linked sialic acid moieties found on epithelial, endothelial, B, and T cells. This binding can be masked by cis interactions with sialic acids on the same cell surface. CD22 expression is limited to late stages of B-cell differentiation, making it useful for phenotyping mature leukemias. Intracellularly, CD22 features six tyrosine residues within immunotyrosine-based inhibitory motifs (ITIM) and activation-like motifs. These residues are phosphorylated upon B-cell receptor engagement, allowing CD22 to regulate B-cell receptor signaling. CD22 participates in positive regulation through interactions with Src family tyrosine kinases and acts as an inhibitory receptor by recruiting cytoplasmic phosphatases via SH2 domains, which block signal transduction through dephosphorylation of signaling molecules. CD22's role in both positive and negative regulation of B-cell signaling, along with its specific expression pattern, makes it a valuable marker for antibody customers interested in B-cell-related research and diagnostics. SWISS: P20273 Gene ID: 933 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Human spleen tissue slide using IHC0556H (Human CD22 Kit).
Immunohistochemical analysis of paraffin embedded Human tonsil tissue slide using IHC0556H (Human CD22 Kit).
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