| 產(chǎn)品編號(hào) | IHC0548H |
| 英文名稱 | Human Phospho-MDM2 (Ser166) Ready-To-Use IHC Kit |
| 中文名稱 | 人磷酸化雙微體2癌基因即用型免疫組化試劑盒 |
| 別 名 | ACTFS; hdm2; HDMX; MDM2; MDM2 (phospho T218); MDM2 (phospho Thr218); p-MDM2 (T218); p-MDM2 (Thr218); Double minute 2 protein; Hdm 2; HDM2; MDM 2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa; MDM2BP; Mouse Double Minute 2; MTBP; Murine Double Minute Chromosome 2; Oncoprotein Mdm2; p53 Binding Protein Mdm2; Ubiquitin protein ligase E3 Mdm2; MDM2_HUMAN; E3 ubiquitin-protein ligase Mdm2 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53. MDM2 is located on chromosome 12 on the q arm. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53. MDM2 has also been shown to negatively regulate p53 function. MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function. Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity. Further, MDM2 plays important roles in apoptosis and cell cycle. MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer. In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues. SWISS: Q00987 Gene ID: 4193 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Human gastric cancer tissue slide using IHC0548H (Human Phospho-MDM2 (Ser166) Kit).
Immunohistochemical analysis of paraffin embedded Human placenta tissue slide using IHC0548H (Human Phospho-MDM2 (Ser166) Kit).
Immunohistochemical analysis of paraffin embedded Human ovary tissue slide using IHC0548H (Human Phospho-MDM2 (Ser166) Kit).
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Immunohistochemical analysis of paraffin embedded Human colon cancer tissue slide using IHC0548H (Human Phospho-MDM2 (Ser166) Kit).
Immunohistochemical analysis of paraffin embedded Human hepatocellular carcinoma tissue slide using IHC0548H (Human Phospho-MDM2 (Ser166) Kit).
Immunohistochemical analysis of paraffin embedded Human liver tissue slide using IHC0548H (Human Phospho-MDM2 (Ser166) Kit).
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