| 產(chǎn)品編號(hào) | D50679 |
| 英文名稱 | LY 294002 |
| 中文名稱 | |
| 別 名 | PI3K抑制劑 |
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Specific References (2) | D50679 has been referenced in 2 publications.
[IF=5.131] Kang Lu. et al. Micropattern Silk Fibroin Film Facilitates Tendon Repair In Vivo and Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells through the α2β1/FAK/PI3K/AKT Signaling Pathway In Vitro. STEM CELLS INT. 2023 Jan 13;2023:2915826
[IF=2.813] Lu, Kang. et al. N-Acetyl-L-cysteine facilitates tendon repair and promotes the tenogenic differentiation of tendon stem/progenitor cells by enhancing the integrin α5/β1/PI3K/AKT signaling. BMC MOL CELL BIOL. 2023 Dec;24(1):1-13
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| CAS | 154447-36-6 |
| 理論分子量 | kDa |
| 檢測(cè)分子量 | |
| 保存條件 | Store at -20℃ for 3 year(Powder); In DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
CAS：154447-36-6 分子式：C19H18ClNO3 分子量：343.8 MDL：MFCD00270881 純度：≥99.95% (HPLC) 溶解性：溶于DMSO, 作用靶點(diǎn)：PI3K; Casein Kinase; DNA-PK; Autophagy; Apoptosis; 作用通路：PI3K/Akt/mTOR; Cell Cycle/DNA Damage; Stem Cell/Wnt; Autophagy; Apoptosis; 產(chǎn)品描述：LY294002 是一種廣譜 PI3K 抑制劑，抑制 PI3Kα, PI3Kδ 和 PI3Kβ 的 IC50 分別為 0.5, 0.57, 0.97 μM。LY294002 也可抑制 CK2 的活性，IC50 為 98 nM。LY294002 是一種競(jìng)爭(zhēng)性 DNA-PK 抑制劑，可逆結(jié)合 DNA-PK 的激酶結(jié)構(gòu)域，IC50 為 1.4 μM。LY294002 是一種自噬 (autophagy) 和凋亡 (apoptosis) 激活劑。 |
