| 產(chǎn)品編號(hào) | IHC0358 |
| 英文名稱 | WT1 Ready-To-Use IHC Kit |
| 中文名稱 | 腎母細(xì)胞瘤蛋白即用型免疫組化試劑盒 |
| 別 名 | AWT1, D630046I19Rik, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, Wt-1, WT1, WT33, Wilms tumor 1 |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
The Wilms Tumor 1 gene encodes one of the WPP domain-interacting proteins (Wilms Tumor 1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). Wilms Tumor 1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded mouse kidney tissue slide using IHC0358 (WT1 Kit).
Immunohistochemical analysis of paraffin embedded human kidney tissue slide using IHC0358 (WT1 Kit).
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