| 產(chǎn)品編號 |
IHC0337H |
| 英文名稱 |
Human Dnmt3a Ready-To-Use IHC Kit
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| 中文名稱 |
人DNA甲基轉(zhuǎn)移酶-3α即用型免疫組化試劑盒 |
| 別 名 |
DNMT3A, MmuIIIA, TBRS, DNA (cytosine 5 ) methyltransferase 3 alpha, DNA (cytosine 5) methyltransferase 3A, DNA cytosine methyltransferase 3A2, DNA methyltransferase 3a, DNA methyltransferase HsaIIIA, DNA MTase HsaI, DNA MTase HsaIIIA, DNMT 3a, DNMT, DNMT3 |
| 保存條件 |
Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.
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| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human placenta tissue slide using IHC0337H (Human Dnmt3a Kit).
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