| 產(chǎn)品編號 | IHC0329R |
| 英文名稱 | Rat LGR5/GPR49 Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠蛋白偶聯(lián)受體49即用型免疫組化試劑盒 |
| 別 名 | FEX, GPR49, GPR67, GRP49, HG38, LGR5 |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
G protein-coupled receptor GPR49 has been reported to be expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries and from human germ cell, uterus, and brain libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded rat pancreas tissue slide using IHC0329R (Rat LGR5/GPR49 Kit).
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