| 產(chǎn)品編號 | IHC0324R |
| 英文名稱 | Rat BDNF Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠腦源神經(jīng)營養(yǎng)因子即用型免疫組化試劑盒 |
| 別 名 | ANON2, BULN2, Abrineurin, BDNF, BDNF_HUMAN, Brain Derived Neurotrophic Factor, Brain-derived neurotrophic factor, MGC34632, MGC34632, Neurotrophin |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded rat brain tissue slide using IHC0324R (Rat BDNF Kit).
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