| 產(chǎn)品編號(hào) | IHC0320H |
| 英文名稱 | Human CD206 Ready-To-Use IHC Kit |
| 中文名稱 | 人巨噬細(xì)胞甘露糖受體 即用型免疫組化試劑盒 |
| 別 名 | bA541I19.1, CD206, CLEC13D, CLEC13DL, hMR, MMR, MRC1, MRC1L1, Macrophage mannose receptor 1, Mannose receptor, mannose receptor, C type 1 |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human spleen tissue slide using IHC0320H (Human CD206 Kit).
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Immunohistochemical analysis of paraffin embedded human colon tissue slide using IHC0320H (Human CD206 Kit).
Immunohistochemical analysis of paraffin embedded human liver tissue slide using IHC0320H (Human CD206 Kit).
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