| 產(chǎn)品編號(hào) | IHC0311R |
| 英文名稱 | Rat MMP9 Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠基質(zhì)金屬蛋白酶-9即用型免疫組化試劑盒 |
| 別 名 | AW743869, B/MMP9, pro-MMP-9, Matrix metalloproteinase-9 precursor, MMP-9, MMP9, MMP 9, 92 kDa type IV, Collagenase, 92 kDa gelatinase, Gelatinase B, GELB, MMP9_HUMAN, 82 kDa matrix metalloproteinase-9, 92 kDa type IV collagenase, CLG 4B, CLG-4B, CLG4B, Co |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded rat spleen tissue slide using IHC0311R (Rat MMP9 Kit).
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