| 產(chǎn)品編號(hào) | IHC0306H |
| 英文名稱 | Human CD74 Ready-To-Use IHC Kit |
| 中文名稱 | 人CD74即用型免疫組化試劑盒 |
| 別 名 | CD74, HLADG, Ia-GAMMA, II, CD 74, CD74 antigen, CD74 molecule, CLIP, DHLAG, Gamma chain of class II antigens, HG2A_HUMAN, HLA class II histocompatibility antigen gamma chain, HLA DR antigens associated invariant chain, HLA DR gamma, HLA-DR antigens-associ |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human spleen tissue slide using IHC0306H (Human CD74 Kit).
Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0306H (Human CD74 Kit).
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