| 產(chǎn)品編號(hào) | IHC0391M |
| 英文名稱 | Mouse LAMP2 Ready-To-Use IHC Kit |
| 中文名稱 | 小鼠溶酶體相關(guān)膜蛋白2（CD107B）即用型免疫組化試劑盒 |
| 別 名 | Lamp II, Lamp-2a, Lamp-2b, Lamp-2c, LAMP2, LAMPB, LGP-B, LGP110, Mac3, CD107 antigen-like family member B, CD107b, CD107b antigen, Igp110, Igp2, LAMP 2, LAMP 2C, LAMP B, LAMP-2, LAMP2_RAT, LAMPB, LGP110 |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C. LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation. LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon’s disease). |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded mouse kidney tissue slide using IHC0391M (Mouse LAMP2 Kit).
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