| 產(chǎn)品編號(hào) | IHC0388H |
| 英文名稱 | Human Granzyme B Ready-To-Use IHC Kit |
| 中文名稱 | 人顆粒酶B即用型免疫組化試劑盒 |
| 別 名 | CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, GRB, GZMB, HLP, SECT, C11 |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified. |
| 產(chǎn)品圖片 |
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Immunohistochemical analysis of paraffin embedded human colon cancer tissue slide using IHC0388H (Human Granzyme B Kit).
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Immunohistochemical analysis of paraffin embedded human colon tissue slide using IHC0388H (Human Granzyme B Kit).
Immunohistochemical analysis of paraffin embedded human lung tissue slide using IHC0388H (Human Granzyme B Kit).
Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0388H (Human Granzyme B Kit).
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