| 產(chǎn)品編號 |
IHC0387M |
| 英文名稱 |
Mouse phospho-STAT3 (Ser727) Ready-To-Use IHC Kit
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| 中文名稱 |
小鼠磷酸化信號轉導和轉錄激活因子3即用型免疫組化試劑盒 |
| 別 名 |
1110034C02Rik, ADMIO, ADMIO1, AW109958, HIES, STAT3, STAT3 (phospho S727), p-STAT3 (phospho S727), STAT3(Phospho Ser727), STAT3(Phospho S727), p-STAT3(Ser727), Acute Phase Response Factor, APRF, DNA binding protein APRF |
| 保存條件 |
Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3. STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on the q arm of chromosome 17. STAT3 has been shown to be activated by IFN-alpha but not IFN-beta. The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3 while the PIAS3 protein is a specific inhibitor of STAT3. Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described. Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage.
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| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded mouse brain tissue slide using IHC0387M (Mouse phospho-STAT3 (Ser727) Kit).
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