| 產(chǎn)品編號(hào) | D58209 |
| 英文名稱 | AMG-1694 |
| 中文名稱 | |
| CAS | 1361217-07-3 |
| 理論分子量 | 533.63kDa |
| 保存條件 | Powder: -20℃ for 3 years | In solvent: -80℃ for 1 year |
| 產(chǎn)品介紹 |
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. |
