| 產(chǎn)品編號 | D51686 |
| 英文名稱 | TBK1 PROTAC? 3i |
| 中文名稱 | |
| 別 名 | TBK1降解劑 |
| CAS | 2052306-13-3 |
| 理論分子量 | 1093.18kDa |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 產(chǎn)品介紹 |
TBK1 PROTAC廬 3i is a Potent TANK-binding kinase 1 (TBK1) Degrader. It exhibits >50-fold selectivity for TBK1 over the closely related IKKε. It comprises a ligand for von-Hippel Lindau (VHL) protein joined by a linker to a TBK1-targeting moiety. It brings about near complete degradation of TBK1 in mutant K-Ras and wild-type cancer cell lines with no significant effect of proliferation. |
