| 產(chǎn)品編號(hào) | D51685 |
| 英文名稱 | JHU 37160 |
| 中文名稱 | |
| 別 名 | DREADD激動(dòng)劑 |
| CAS | 2369979-68-8 |
| 理論分子量 | 358.84kDa |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 產(chǎn)品介紹 |
JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37160 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. It is a brain penetrant in mice, rats and non-human primates. |
