| 產(chǎn)品編號(hào) | D51631 |
| 英文名稱 | BRD4770 |
| 中文名稱 | |
| 別 名 | Histone methyltransferase G9a抑制劑 |
| CAS | 1374601-40-7 |
| 理論分子量 | 413.47kDa |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 產(chǎn)品介紹 |
BRD4770 is a novel histone methyltransferase inhibitor. BRD4770 reduced cellular levels of di- and trimethylated H3K9 without inducing apoptosis, induced senescence, and inhibited both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. ATM-pathway activation, caused by either genetic or small-molecule inhibition of G9a, may mediate BRD4770-induced cell senescence. BRD4770 may be a useful tool to study G9a and its role in senescence and cancer cell biology. |
