| 產(chǎn)品編號(hào) | D51618 |
| 英文名稱 | Capmatinib HCl hydrate |
| 中文名稱 | |
| 別 名 | c-MET抑制劑 |
| CAS | 1865733-40-9 |
| 理論分子量 | 503.36kDa |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 產(chǎn)品介紹 |
Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor INC280 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. Capmatinib was approved in 2020. |
