| 產(chǎn)品編號(hào) | D50453 |
| 英文名稱 | Okadaic acid |
| 中文名稱 | 岡田酸 |
| 別 名 | OA; Okadaic A; 35-Demethyldinophysistoxin 1 solution; 35-Demethyl-DTX 1 solution; NSC 677083; PP1&PP2A inhibitor; PP1 and PP2A inhibitor; Okadaic acid potassium salt from Prorocentrum; 岡田(軟海綿)酸; 軟海綿酸; 黑海棉酸; 岡田酸/軟海綿酸; 岡田酸 鉀鹽 來源于凹形原甲藻;PP1和PP2A抑制劑 |
| 克 隆 號(hào) | |
| CAS | 155751-72-7 |
| 理論分子量 | kDa |
| 檢測分子量 | |
| 保存條件 | Store at -20℃ stable for 24 months. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
基本信息： CAS：155751-72-7 分子式：C44H67KO13 分子量：843.09
MDL：MFCD00214356 溶解性：溶于乙醇（5 ug/50 ul = 124.2 μM） 產(chǎn)品簡介： 岡田酸 (Okadaic acid) 是一種海洋毒素，是蛋白質(zhì)磷酸酶 (PP) 的抑制劑，包括 PP1 (IC50=15-50 nM)、PP2A (IC50=0.1-0.3 nM)、PP3 (IC50=3.7-4 nM)、PP4 (IC50=0.1 nM) 和 PP5 (IC50=3.5 nM)，其中對 PP2A 的親和力最顯著，但不抑制 PP2C。Okadaic acid 通過抑制 PP 增加了多種蛋白的磷酸化，并具有腫瘤啟動(dòng)子的作用。Okadaic acid 誘導(dǎo) tau 蛋白磷酸化。 作用靶點(diǎn)：Phosphatase; Apoptosis; 作用通路：Metabolic Enzyme/Protease; Apoptosis 體外研究： Okadaic acid (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3]. Okadaic acid (10 nM; 8 hours) increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[3] 體內(nèi)研究： Okadaic acid (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5] REFERENCES： [1]. Kleppe R, et al. Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action. Mar Drugs. 2015 Oct 22;13(10):6505-20. [2]. Valdiglesias V, et al. Okadaic acid: more than a diarrheic toxin. Mar Drugs. 2013 Oct 31;11(11):4328-49. [3]. del Campo M, et al. Okadaic acid toxin at sublethal dose produced cell proliferation in gastric and colon epithelial cell lines. Mar Drugs. 2013;11(12):4751-4760. [4]. Cho MH, et al. Increased phosphorylation of dynamin-related protein 1 and mitochondrial fission in okadaic acid-treated neurons. Brain Res. 2012 May 15;1454:100-10. [5]. Baker S, et al. A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions. Acta Neuropathol Commun. 2016;4:32. |
