| 產(chǎn)品編號(hào) | D50402 |
| 英文名稱 | EX-527 |
| 中文名稱 | |
| 別 名 | EX 527 (Selisistat); 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide; EX527 cpd; Selisistat; SEN0014196; SIRT1 Inhibitor III; HY-15452; Selisistat (EX 527); SIRT1 Inhibitor; SIRT1抑制劑 |
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Specific References (1) | D50402 has been referenced in 1 publications.
[IF=3.329] Su, Pei-Pei. et al. Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy. MILITARY MED RES. 2022 Dec;9(1):1-13 Mouse.
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| 克 隆 號(hào) | |
| CAS | 49843-98-3 |
| 理論分子量 | kDa |
| 檢測(cè)分子量 | |
| 保存條件 | Store at -20℃ stable for at least 12 months. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
CAS：49843-98-3 分子式：C13H13ClN2O 分子量：248.71 MDL：MFCD03009471 純度：≥98% 熔點(diǎn)：178℃ 沸點(diǎn)：531.72℃/760mmHg 溶解性：Soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), DMF (~20 mg/ml), and DMSO:PBS (1:1 pH 7.2) (~0.5 mg/ml). 溶解性：Water <1mg/ml; DMSO 50mg/ml; Ethanol 18mg/ml 作用靶點(diǎn)：Sirtuin; 作用通路：Cell Cycle/DNA Damage; Epigenetics; 用途及描述：Selisistat (EX-527) 是一種有效，選擇性的 SIRT1 抑制劑，IC50 為 98 nM。對(duì)SIRT2和SIRT3極弱的抑制作用。 |
