| 產(chǎn)品編號 | bs-21362R |
| 英文名稱 | NCR1 Rabbit pAb |
| 中文名稱 | 細(xì)胞毒性受體NK-p46抗體 |
| 別 名 | Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335; CD 335; LY94; NCTR1_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 31 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NCR1 : 198-206/304 <Extracellular> |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Subunit: Interacts with CD247 and FCER1G. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Selectively expressed by both resting and activated NK cells. Similarity: Belongs to the natural cytotoxicity receptor (NCR) family. Contains 2 Ig-like (immunoglobulin-like) domains. SWISS: O76036 Gene ID: 9437 Database links: Entrez Gene: 9437 Human Entrez Gene: 17086 Mouse Omim: 604530 Human SwissProt: O76036 Human SwissProt: Q8C567 Mouse Unigene: 97084 Human Unigene: 240231 Mouse Unigene: 30049 Rat NKp46是很重要的的自然細(xì)胞毒受體，在自然殺傷作用中起關(guān)鍵作用。細(xì)胞毒性受體家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表達(dá)于所有靜止和活化的NK細(xì)胞，而NKp44則選擇性的表達(dá)于活化的NK細(xì)胞。靶細(xì)胞上的配體分子與NCRs的結(jié)合（交聯(lián)）引發(fā)NK細(xì)胞的活化導(dǎo)致靶細(xì)胞的裂解和大量細(xì)胞因子的產(chǎn)生。現(xiàn)已確認(rèn)NKp46和NKp44可以識別病毒上的配體分子紅血球凝聚素，而NKp46則能識別腫瘤細(xì)胞上的乙酰硫酸多聚糖。 |
| 產(chǎn)品圖片 |
Spleen (Mouse) Lysate at 40 ug Lung (Mouse) Lysate at 40 ug Kidney (Mouse) Lysate at 40 ug Primary: Anti-NCR1 (bs-21362R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size
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