| 產(chǎn)品編號(hào) | bs-13005R |
| 英文名稱 | DKK2 Rabbit pAb |
| 中文名稱 | DKK2抗體 |
| 別 名 | Dickkopf 2; Dickkopf gene 2; Dickkopf homolog 2; Dickkopf related protein 2; Dickkopf-2; Dickkopf-related protein 2; Dickkopf2; DKK 2; Dkk-2; DKK2_HUMAN; hDkk 2; hDkk-2; hDkk2. |
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Specific References (1) | bs-13005R has been referenced in 1 publications.
[IF=5.011] Juanjuan Li. et al. The effect of 1,25-dihydroxyvitamin D3 on the Wnt signaling pathway in bovine intestinal epithelial cells is mediated by the DKK2 (dickkopf2) Wnt antagonist. J STEROID BIOCHEM. 2023 Jul;231:106319 WB ; Bovine.
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| 研究領(lǐng)域 | 干細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 25 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DKK2: 161-259/259 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Subunit: Interacts with LRP5 and LRP6. Subcellular Location: Secreted. Tissue Specificity: Expressed in heart, brain, skeletal muscle and lung. Post-translational modifications: May be proteolytically processed by a furin-like protease. Similarity: Belongs to the dickkopf family. SWISS: Q9UBU2 Gene ID: 27123 Database links: Entrez Gene: 27123 Human Entrez Gene: 56811 Mouse Omim: 605415 Human SwissProt: Q9UBU2 Human SwissProt: Q9QYZ8 Mouse SwissProt: Q9DDA4 Xenopus laevis Unigene: 211869 Human Unigene: 103593 Mouse |
