| 產(chǎn)品編號(hào) | bs-6601R |
| 英文名稱 | TLR7 Rabbit pAb |
| 中文名稱 | Toll樣受體7抗體 |
| 別 名 | TLR-7; PRO285; TLR 7; TLR7_HUMAN; Toll like receptor 7; Toll-like receptor 7; UNQ248. |
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Specific References (5) | bs-6601R has been referenced in 5 publications.
[IF=10.419] Takashi Umeharaet al. A simple sperm-sexing method that activates TLR7/8 on X sperm for the efficient production of sexed Mouseor cattle embryos. Nat Protoc
. 2020 Aug;15(8):2645-2667. FCM ; mouse.
[IF=8.386] Umehara T et al. Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm. PLoS Biol. 2019 Aug 13;17(8):e3000398. WB ; Mouse.
[IF=8.025] Fei Wen. et al. TLR7/8 agonist (R848) inhibit bovine X sperm motility via PI3K/GSK3α/β and PI3K/NFκB pathways. INT J BIOL MACROMOL. 2023 Mar;232:123485 IF ; Bovine.
[IF=3.777] Ling Shuai. et al. Hydroxychloroquine protects against autoimmune premature ovarian insufficiency by modulating the Treg/Th17 cell ratio in BALB/c mice. AM J REPROD IMMUNOL. 2023 Feb;: WB ; Mouse.
[IF=1.72] Lu, Na-na, et al. "Gene Expression Profiles Underlying Selective T-Cell-Mediated Immunity Activity of a Chinese Medicine Granule on Mice Infected with Influenza Virus H1N1." Evidence-Based Complementary and Alternative Medicine 2014 (2014). WB ; Mouse.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 121 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TLR7: 461-560/1049 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Subcellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Tissue Specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Similarity: Belongs to the Toll-like receptor family. Contains 27 LRR (leucine-rich) repeats. Contains 1 TIR domain. SWISS: Q9NYK1 Gene ID: 51284 Database links: Entrez Gene: 51284 Human Entrez Gene: 170743 Mouse Omim: 300365 Human SwissProt: Q9NYK1 Human SwissProt: P58681 Mouse Unigene: 101913 Cow Unigene: 659215 Human Unigene: 23979 Mouse |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human THP-1(LPS) cell lysates
Lane 2: Human THP-1 cell lysates
Lane 3: Human Jurkat cell lysates
Lane 4: Human MCF-7 cell lysates
Lane 5: Human 293T cell lysates
Primary: Anti-TLR7 (bs-6601R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 121 kDa
Observed band size: 65,121 kDa
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