| 產(chǎn)品編號(hào) | bsm-2027M |
| 英文名稱(chēng) | HCG Beta(4H7) Mouse mAb |
| 中文名稱(chēng) | 人絨毛膜促性腺激素β亞基/β-HCG單克隆抗體 |
| 別 名 | β-HCG; HCG-beta; beta-HCG; beta HCG; CGB3_HUMAN; Choriogonadotropin subunit beta 3; CGB3; CGB; CGB5; CGB8; Choriogonadotropin subunit beta(CG-beta); Chorionic gonadotropin chain beta; HCG; hCGB; CG-beta; βHCG; β HCG. |
| 研究領(lǐng)域 | 免疫學(xué) |
| 抗體來(lái)源 | Mouse |
| 克隆類(lèi)型 | Monoclonal |
| 克 隆 號(hào) | 4H7 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-100000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 16 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | HCG Beta protein |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M PBS (pH7.4) with 0.02% Proclin300. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008] Function: Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates. Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin. Subcellular Location: Secreted. Tissue Specificity: Placenta. Similarity: Belongs to the glycoprotein hormones subunit beta family. Database links:
Entrez Gene: 1082 Human Entrez Gene: 93659 Human Entrez Gene: 94027 Human Entrez Gene: 94115 Human Omim: 118860 Human SwissProt: P01233 Human SwissProt: Q6NT52 Human SwissProt: P0DN86 Human
HCG是由胎盤(pán)合體滋養(yǎng)層細(xì)胞產(chǎn)生的一種糖蛋白激素，主要用于胎盤(pán)滋養(yǎng)細(xì)胞和生殖細(xì)胞腫瘤如葡萄胎、絨癌的診斷和輔助診斷。 |
| 產(chǎn)品圖片 |
Measured by its binding ability in a indirect ELISA. Immobilized Human HCG Beta protein, HisTag (Cat. bs-43085P) at 2 μg/mL (100 μL/well) can bind Mouse Anti-Human HCG Beta Antibody, the EC50 is 27.39 ng/mL.
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