| 產(chǎn)品編號 | bs-0466R |
| 英文名稱 | Beta casein Rabbit pAb |
| 中文名稱 | β-酪蛋白抗體 |
| 別 名 | beta-casein; CASB; CASB_SHEEP; Casein beta; CSN 2; Csn2. |
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Specific References (14) | bs-0466R has been referenced in 14 publications.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human,Sheep,Cow,Goat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from sheep Beta-casein: 151-222/222 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Multiple binding sites for Stat5, C/EBPb (CCAAT/enchancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regulator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation. Function: Important role in determination of the surface properties of the casein micelles. Subcellular Location: Secreted. Tissue Specificity: Mammary gland specific. Secreted in milk. Similarity: Belongs to the beta-casein family. Gene ID: 443391 Database links: Entrez Gene: 443391 Sheep Entrez Gene: 1447 Human Omim: 115460 Human SwissProt: P05814 Human Unigene: 2242 Human β-酪蛋白常在乳腺表達(dá)，山羊、綿羊同源 分子量：25kDa |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Milk (Goat) Lysate at 2 ug
Lane 2: Milk (Cow) Lysate at 30 ug
Lane 3: Milk (Cow) Lysate at 3 ug
Lane 4: Milk (Human) Lysate at 30 ug
Primary: Anti-Beta-casein (bs-0466R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 23 kD
Observed band size: 25-29 kD
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