| 產(chǎn)品編號(hào) | IHC0298H |
| 英文名稱 | Human CD11b Ready-To-Use IHC Kit |
| 中文名稱 | 人整合素αM即用型免疫組化試劑盒 |
| 別 名 | CD11B; CR3A; ITGAM; MAC-1; MAC1A; MO1A; SLEB6; antigen CD11b (p170); Antigen CD11b p170; CD11 antigen like family member B; CD11 antigen-like family member B; CD11b; CD11b/CD18; CD49d; Cell surface glycoprotein MAC-1 subunit alpha; Complement component 3 |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human cerebellum tissue slide using IHC0298H (Human CD11b IHC Kit).
Immunohistochemical analysis of paraffin embedded human spleen tissue slide using IHC0298H (Human CD11b IHC Kit).
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Immunohistochemical analysis of paraffin embedded human colon cancer tissue slide using IHC0298H (Human CD11b IHC Kit).
Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0298H (Human CD11b IHC Kit).
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