| 產(chǎn)品編號(hào) | IHC0198R |
| 英文名稱 | Rat Integrin alpha 2 Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠整合素α2（CD49b）即用型免疫組化試劑盒 |
| 別 名 | CD49B; HPA-5; ITGA2; VLA-2; VLAA2; Integrin alpha 2; CD49b antigen; BR; CD 49b; CD49 antigen like family member B; CD49b; Collagen receptor; DX5; Glycoprotein Ia deficiency included; GP Ia; GP Ia deficiency;included; GPIa; HPA 5 included; HPA5 included; I |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3. |
| 產(chǎn)品圖片 |
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Immunohistochemical analysis of paraffin embedded rat colon tissue slide using IHC0198R (Rat Integrin alpha 2 IHC Kit).
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