| 產(chǎn)品編號 | IHC0190H |
| 英文名稱 | Human CD8 Ready-To-Use IHC Kit |
| 中文名稱 | 人CD8即用型免疫組化試劑盒 |
| 別 名 | CD8; CD8A; CD8B; CD8B1; LEU2; LY3; LYT3; MAL; p32; P37; CD8 antigen; alpha polypeptide (p32); CD8a; CD8a antigen; CD8a molecule; CD8A_HUMAN; Leu2; Leu2 T lymphocyte antigen; MAL; OKT8 T cell antigen; T cell antigen Leu2; T cell co receptor; T-cell surface |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human small intestine tissue slide using IHC0190H (Human CD8 IHC Kit).
Immunohistochemical analysis of paraffin embedded human spleen tissue slide using IHC0190H (Human CD8 IHC Kit).
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Immunohistochemical analysis of paraffin embedded human colon cancer tissue slide using IHC0190H (Human CD8 IHC Kit).
Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0190H (Human CD8 IHC Kit).
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