| 產(chǎn)品編號 | IHC0175R |
| 英文名稱 | Rat Tau-4 Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠微管相關(guān)蛋白Tau-4即用型免疫組化試劑盒 |
| 別 名 | AI413597; AW045860; DDPAC; FTDP-17; MAPT; MAPTL; MSTD; Mtapt; MTBT1; MTBT2; PPND; PPP1R103; pTau; RNPTAU; TAU; Microtuble-associted protein Tau; Disinhibition dementia parkinsonism amyotrophy complex; FLJ31424; FTDP 17; FTDP17; G Protein beta 1 gamma 2 su |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded rat spleen tissue slide using IHC0175R (Rat Tau-4 IHC Kit).
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Immunohistochemical analysis of paraffin embedded rat colon tissue slide using IHC0175R (Rat Tau-4 IHC Kit).
Immunohistochemical analysis of paraffin embedded rat lung tissue slide using IHC0175R (Rat Tau-4 IHC Kit).
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