| 產(chǎn)品編號(hào) | IHC0281H |
| 英文名稱 | Human Bax Ready-To-Use IHC Kit |
| 中文名稱 | 人Bax即用型免疫組化試劑盒 |
| 別 名 | BAX; BCL2L4; Bcl2-L-4; Bax-protein; BAX_HUMAN; BAXA |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human lung cancer tissue slide using IHC0281H (Human Bax IHC Kit).
Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0281H (Human Bax IHC Kit).
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