| 產(chǎn)品編號 | bs-21006R-Gold |
| 英文名稱1 | Rabbit Anti-PAIP1/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的多聚腺苷酸結(jié)合蛋白相互作用蛋白1抗體 |
| 別 名 | MGC12360; OTTHUMP00000221601; OTTMUSP00000026880; PABC1 interacting protein 1; PABP interacting protein 1; PABP-interacting protein 1; PAIP 1; PAIP-1; Paip1; PAIP1_HUMAN; Poly(A) binding protein interacting protein 1; Poly(A)-binding protein-interacting protein 1; Polyadenylate binding protein interacting protein 1; Polyadenylate-binding protein-interacting protein 1. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 結(jié)合蛋白 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PAIP1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008] Function: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Subcellular Location: Cytoplasm. Similarity: Contains 1 MIF4G domain. Database links: Entrez Gene: 10605 Human Entrez Gene: 218693 Mouse Omim: 605184 Human SwissProt: Q9H074 Human SwissProt: Q8VE62 Mouse Unigene: 482038 Human Unigene: 132584 Mouse Unigene: 9450 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
