| 產(chǎn)品編號 | bs-19968R-PE-Cy3 |
| 英文名稱1 | Rabbit Anti-PPP2R2D/PE-Cy3 Conjugated antibody |
| 中文名稱 | PE-Cy3標(biāo)記的蛋白磷酸酶2調(diào)節(jié)亞基2D抗體 |
| 別 名 | 2ABD_HUMAN; MDS026; PP2A subunit B isoform B55-delta; PP2A subunit B isoform delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PPP2R2D; Protein phosphatase 2 regulatory subunit B delta; Protein phosphatase 2 regulatory subunit B delta isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Horse, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PPP2R2D |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
Function: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity). Subcellular Location: Cytoplasm. Similarity: Belongs to the phosphatase 2A regulatory subunit B family. Contains 7 WD repeats. Database links: Entrez Gene: 423970 Chicken Entrez Gene: 55844 Human Entrez Gene: 52432 Mouse Entrez Gene: 379305 Xenopus laevis Entrez Gene: 448324 Xenopus tropicalis Entrez Gene: 327263 Zebrafish Omim: 613992 Human SwissProt: Q5ZIY5 Chicken SwissProt: Q4R8L3-2 Cynomolgus Monkey SwissProt: Q66LE6 Human SwissProt: Q925E7 Mouse SwissProt: Q5R4A2 Orangutan SwissProt: P63150 Rabbit SwissProt: Q7ZX64 Xenopus laevis SwissProt: Q6DIY3 Xenopus tropicalis SwissProt: Q6NY64 Zebrafish Unigene: 380372 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
