| 產(chǎn)品編號(hào) | bs-19560R-Gold |
| 英文名稱1 | Rabbit Anti-OBFC1/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的α輔助因子44抗體 |
| 別 名 | AAF 44; AAF44; Alpha accessory factor 44; bA541N10.2; CST complex subunit STN1; FLJ22559; Obfc1; Oligonucleotide/oligosaccharide binding fold containing 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; OTTHUMP00000020417; OTTHUMP00000020418; Replication protein A 32 kDa subunit; RP11-541N10.2; RPA 32; STN1; STN1_HUMAN; Suppressor of cdc thirteen; Suppressor of cdc thirteen homolog. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 結(jié)合蛋白 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Horse, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OBFC1/AAF44 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009] Function: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Subcellular Location: Nucleus. Chromosome > telomere. Similarity: Belongs to the STN1 family. Contains 1 OB DNA-binding domain. Database links: Entrez Gene: 79991 Human Entrez Gene: 108689 Mouse Omim: 613128 Human SwissProt: Q9H668 Human SwissProt: Q8K2X3 Mouse Unigene: 62314 Human Unigene: 218048 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
