| 產(chǎn)品編號(hào) | bs-23114R-APC |
| 英文名稱1 | Rabbit Anti-Intersectin 2/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的Intersectin 2抗體 |
| 別 名 | Intersectin-2; ITSN2; ITSN2_HUMAN; KIAA1256; PRO2015; SH3 domain-containing protein 1B; SH3D1B; SH3P18; SH3P18-like WASP-associated protein; SWA; SWAP. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) G蛋白信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 193kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Intersectin 2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Intersectin, which is also designated Ese1 or ITSN1, is a component of the cellular endocytic machinery. Intersectin is composed of two N-terminal Ese15 homology (EH) domains, a central highly charged region and five C-terminal SH3 domains, which all largely contribute to the association of Intersectin with other components of the endocytic pathway. The EH domain is particularly responsible for the directed localization of Intersectin to Clathrin-coated pits near the plasma membrane. Within the endocytic vesicles the SH3 domains facilitate the binding of Intersectin with Dynamin, and the central domain is essential for the association of Intersectin with SNAP 25. Two isoforms of Intersectin are produced as a result of alternative splicing in a stop codon, and they are designated as Intersectin-short and long (or IntersectinS and IntersectinL) to reflect an extended C-terminal domain. The long form, which has an extended C-terminal domain, is specifically expressed in neurons; the short form is detected in both glial and nonneuronal cells. The related proteins Intersectin-2 and the murine homolog Ese2 also contain the characteristic N-terminal EH domains, the central coiled-coil domain and five C-terminal SH3 domains and are likely involved the endocytic scaffolding complexes. Function: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Subunit: Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according to the step in the endocytic process. Interacts with ADAM15. Interacts with FASLG. Interacts with ANKRD54. Interacts with FCHO2. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver. Similarity: Contains 1 C2 domain. Contains 1 DH (DBL-homology) domain. Contains 2 EF-hand domains. Contains 2 EH domains. Contains 1 PH domain. Contains 5 SH3 domains. Database links: Entrez Gene: 50618 Human Omim: 604464 Human SwissProt: Q9NZM3 Human Unigene: 432562 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
