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Rabbit Anti-MHF1/CENPS/Gold Conjugated antibody (bs-18928R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-18928R-Gold
英文名稱1 Rabbit Anti-MHF1/CENPS/Gold Conjugated antibody
中文名稱 膠體金標記的著絲粒蛋白S抗體
別    名 APITD1; Apoptosis-inducing TAF9-like domain-containing protein 1; apoptosis-inducing, TAF9-like domain 1; CENP-S; CENP S; CENPS_HUMAN; Centromere protein S; FAAP16; FANCM-interacting histone fold protein 1; Fanconi anemia-associated polypeptide of 16 kDa; MGC32686; MHF 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  免疫學  細胞周期蛋白  結合蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MHF1/CENPS
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011]

Function:
DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recorery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. As a component of the APITD1/CENPS complex, is also essential for the stable assembly of the outer kinetchore. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.

Subcellular Location:
Nucleus. Chromosome > centromere. Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Tissue Specificity:
Ubiquitously expressed.

Similarity:
Belongs to the TAF9 family.

Database links:

Entrez Gene: 100526739 Human

Entrez Gene: 378708 Human

Omim: 609130 Human

SwissProt: Q8N2Z9 Human

Unigene: 412311 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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