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Rabbit Anti-NCKX2/PE-Cy3 Conjugated antibody (bs-19050R-PE-Cy3)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-19050R-PE-Cy3
英文名稱1 Rabbit Anti-NCKX2/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的視網(wǎng)膜鈉/鉀/鈣交換體2抗體
別    名 Na(+)/K(+)/Ca(2+) exchange protein 2; Na(+)/K(+)/Ca(2+)-exchange protein 2; NCKX 2; NCKX2_HUMAN; OTTHUMP00000045115; Retinal cone Na Ca+K exchanger; Retinal cone Na-Ca+K exchanger; SLC24A2; Sodium/potassium/calcium exchanger 2; solute carrier family 24 (sodium/potassium/calcium exchanger) member 2; Solute carrier family 24 member 2.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NCKX2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Function:
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

Subcellular Location:
Membrane.

Similarity:
Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.

Database links:

Entrez Gene: 25769 Human

Entrez Gene: 76376 Mouse

Entrez Gene: 84550 Rat

Omim: 609838 Human

SwissProt: Q9UI40 Human

SwissProt: O54701 Rat

Unigene: 283014 Human

Unigene: 208755 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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