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Rabbit Anti-IMPG2/BF594 Conjugated antibody (bs-16627R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-16627R-BF594
英文名稱1 Rabbit Anti-IMPG2/BF594 Conjugated antibody
中文名稱 BF594標記的IMPG2蛋白抗體
別    名 Interphotoreceptor matrix proteoglycan 2; Interphotoreceptor matrix proteoglycan 200; Interphotoreceptor matrix proteoglycan of 200 kDa; IPM 200; IPM200; IMPG2_HUMAN; Sialoprotein associated with cones and rods proteoglycan; SPACRCAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  免疫學  神經(jīng)生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 136kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IMPG2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis pigmentosa type 56 and maculopathy, IMPG2-related.[provided by RefSeq, Mar 2011]

Function:
IMPG2 (Interphotoreceptor matrix proteoglycan 2) is part of an extracellular complex occupying the interface between photoreceptors and the retinal pigment epithelium in the fundus of the eye. IMPG2 is part of an extracellular complex occupying the interface between photoreceptors and the retinal pigment epithelium in the fundus of the eye.

Subcellular Location:
Membrane; Single pass type I membrane protein

Tissue Specificity:
Expressed in the retina. Expressed by photoreceptors of the interphotoreceptor matrix (IPM) surrounding both rods and cones. IPM occupies the subretinal space between the apices of the retinal pigment epithelium and the neural retina. Detected in the pineal gland.

Post-translational modifications:
Highly glycosylated (N- and O-linked carbohydrates).

DISEASE:
Retinitis pigmentosa 56 (RP56) [MIM:613581]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note=The disease is caused by mutations affecting the gene represented in this entry.
Maculopathy, IMPG2-related (MACLP-IMPG2) [MIM:613581]: A mild maculopathy characterized by full-field electroretinogram responses within normal limits, normal color vision, elevation of the photoreceptor layer in the foveal region and mild nuclear sclerosis. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 2 EGF-like domains.
Contains 2 SEA domains.

Database links:

Entrez Gene: 50939 Human

Entrez Gene: 224224 Mouse

Entrez Gene: 245919 Rat

Omim: 607056 Human

SwissProt: Q9BZV3 Human

SwissProt: Q80XH2 Mouse

SwissProt: P70628 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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