| 產(chǎn)品編號 | bs-16081R-BF488 |
| 英文名稱1 | Rabbit Anti-FGD5/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的FGD5蛋白抗體 |
| 別 名 | FYVE, RhoGEF and PH domain containing protein 5; ZFYVE23; FGD5_HUMAN; Zinc finger FYVE domain containing protein 23. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 160kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FGD5 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: FGD5 is a 1,462 amino acid cytosolic protein that contains a DH domain, a FYVE-type zinc finger and two PH domains. FGD family members encode guanine nucleotide exchange factors that specifically activate the Rho GTPase Cdc42. All FGD proteins contain equivalent signaling domains and a conserved structural organization, which strongly suggests that these signaling domains form a canonical core structure for members of the FGD family of RhoGEF proteins. These proteins also control essential signals required during embryonic development. Function: FGD5 may activate CDC42, a member of the Ras like family of Rho and Rac proteins, by exchanging bound GDP for free GTP. It may also play a role in regulating the actin cytoskeleton and cell shape. FGD5 contains one DH (DBL-homology) domain one FYVE type zinc finger and two PH domains. There are two isoforms. Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5. Tissue Specificity: Expressed in endothelial cells (at protein level). Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 FYVE-type zinc finger. Contains 2 PH domains. Database links: Entrez Gene: 152273 Human Entrez Gene: 232237 Mouse Omim: 614788 Human SwissProt: Q6ZNL6 Human SwissProt: Q80UZ0 Mouse Unigene: 412406 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
